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Professor Manfred SCHLOSSER
Ecole polytechnique fédérale de Lausanne
Institut des sciences et ingénierie chimiques
EPFL SB ISIC-GE
BCH 4307
CH-1015 Lausanne
Tel.: +41 (0)21
693 93 51
Tel.: +41
(0)21 693 93 60 (secretary)
Fax: +41 (0)21 693 93
65
E-mail:
manfred.schlosser@epfl.ch
Office:
BCH 4307
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CAREER |
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Born in Ludwigshafen on Rhine
(Germany), Manfred Schlosser studied chemistry
and, to a lesser extent, medicine at the
University of Heidelberg. He accomplished a
thesis work under the guidance of Professor
Georg Wittig and was awarded the equivalence of
a PhD degree in 1960. After the "habilitation"
(1966), he was appointed as a senior physician
at the German Cancer Research Center where
he initiated a program
for the synthesis of novel cytostatics. In 1971
he followed a call to the University of Lausanne
where he became the successor of Professor Jiři
Sicher. Later (in 2001) his laboratory was
transferred to the local branch of the Federal
Institute of Technology. Enjoying the emeritus
status since summer 2004, he can entirely focus
on research, lecturing and consulting.
RESEARCH PROFILE
Most of his research topics are located at the
intersection between physical organic chemistry
and applied synthesis. Thus, his stereoselective
olefination procedures ("Schlosser modifications
of the Wittig reaction"), the copper-catalyzed
alkylation of organomagnesium compounds ("Fouquet-Schlosser
coupling") and the mixed-metal reagents (such as
LIC-KOR, the "Schlosser superbase") were all
developed on the basis of new insight acquired
in fundamentally designed investigations.
His concepts and findings in the area of polar
organometallic chemistry constitute a major
chapter in the multi-authored book "Organometallics
in Synthesis . A Manual", a second edition of
which was released in 2002. He was co-organizer
of the second IUPAC symposium on Organometallic
Chemistry Oriented Toward Organic Synthesis
(held in 1983). He was for more than a decade
member of the committee preparing the
Stereochemistry Conferences held annually on
the Bürgenstock (near Lucerne), where he also
organized in 2003 an industry-sponsored
international symposium on "Fluorine in the Life
Sciences".
LINKS
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List of Publications
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The complete list of publications
presently comprises 34 Monographs and
Reviews, 311 Research Articles and
Communications, 74 printed Lecture
Summaries, 11 Editorial Activities, 4
Miscellaneous Items and 3 Patents. This
compilation can be obtained upon request
by e-mail. |
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Fluorine Catalogue |
A documentation of fluorine-containing
building blocks for pharmaceutical and
agri-cultural development is distributed
upon request. These derivatives, which
feature novel substituent pattern have
been made readily accessible by virtue
of the "toolbox methods" for the
regiochemically exhaustive
functionalization of core compounds. |
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Personal Collection of Chemistry
Journals |
Manfred Schlosser owns a library of
major chemistry journals such as
Synthesis (he was the first editor),
Angew. Chem., Helv. Chim. Acta, J. Am.
Chem. Soc., J. Org. Chem., Tetrahedron
Lett., Gazz. Chim. Ital. and Heteroatom
Chem. covering the period of 1960 –
1995. Many of these journals are
hard-cover and cloth bound. Lacking space, he wishes to donate the
collection to an academic institution or
to sell it to a company. |
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In the recent past one of our main objectives
was to make building blocks with uncommon
substituent patterns available for research work
in the life science area. To this end, we have
prepared new fluoro-, chloro- bromo- and
trifluoromethyl-substituted naphthalenes (list
II [299], [308]), phenols (II [285], [294],
[297]), pyridines (II [284], [289], [290],
[292], [296], [301], [306]), quinolines (II
[297], [282], [293]) and pyrimidines (II [286]).These
compounds served as substrates for selective
metalation and subsequent functionalization, for
example by carboxylation. Regiochemical control
was a key issue in all these studies. The
already established methods securing optional
site selectivity by substrate/reagent matching
and protective group selection were further
developed and refined (II [289], [290], [292],
[294], [300], [301], [307]). These efforts
culminated in the concept of regiochemically
exhaustive substitutions through organometallic
intermediates (II [285], [288], [297], [302]).
It relies to a large extent on modern
modifications ("toolbox methods") of hydrogen/metal
and halogen/metal interconversions. In this
context, amazing phenomena were discovered, in
particular the possibility to subject 2-silyl-protected
1,3-dichlorobenzenes to either the classical
ortho or, capitalizing on buttressing effect,
meta metalation (II [291], [310], [311]) and to
prevent or promote at will ("stop-and-go") the
heavy halogen migration in 2-bromo-3-fluorophenyllithium
(II [298]). Further work focused on fundamental
issues such as the CH-acidity of fluoro- and
chlorobenzenes (II [295], [304]) and novel
atropisomeric ligands for asymmetric catalysis
(II [280], [281], [283], [309]).
The 2006 output will again represent a blend
between topics of practical applicability,
mainly in relation with organic synthesis, and
insight-oriented fundamental investigations.
Reports are in preparation featuring an
unprecedented type of stereocontrol inherent in
the twofold Wittig rearrangement of allyl aryl
ethers; the regioexhaustive functionalization of
fluoro- and trifluoromethyl-bearing indoles; a
variety of buttressing-impeded or -rerouted
organometallic reactions; heterosubstituent
effects on the kinetic and thermodynamic acidity
of arenes and the strange reactivity/selectivity
profile of allylpotassium and benzylpotassium
species.
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I.
MONOGRAPHS AND REVIEW ARTICLES |
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1988 |
[21] |
Superbases
for Organic Synthesis.
M. Schlosser
Pure Appl.
Chem. 60 (1988), 1627 - 1634. |
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1992 |
[22] |
Superbases as Powerful Tools in Organic
Synthesis.
M. Schlosser
Modern Synthetic Methods 6 (1992), 227 -
271. |
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1993 |
[23] |
Polar Allyl
Type Organometallics as Key
Intermediates in Regio- and
Stereocontrolled Reactions :
Conformational Mobilities and
Preferences.
M. Schlosser, O. Desponds, R. Lehmann,
E. Moret, G. Rauchschwalbe
Tetrahedron 49 (1993), 10175 - 10203. |
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1994 |
[24] |
Site
Selective Hydrogen/Metal Exchange :
Competition and Cooperation Between
Superbases and Neighboring Groups.
M. Schlosser, F. Faigl, L. Franzini, H.
Geneste, G. Katsoulos, G.-f. Zhong.
Pure Appl. Chem. 66 (1994), 1439 - 1446. |
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[25] |
Organoalkali
Reagents.
M. Schlosser
Organometallics in Synthesis : A Manual
(ed. : M. Schlosser), Wiley, Chichester,
1994, 1 - 164. |
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1996 |
[25a] |
Organoalkali
Reagents.
M. Schlosser
Organometallics in Synthesis : A Manual
(ed. : M. Schlosser), Wiley, Chichester,
1996, 1 - 164 : paperback edition |
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[26] |
About Bases
and Superbases.
F. Mongin, R. Maggi, M. Schlosser
Chimia 50 (1996), 650 - 652. |
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1998 |
[27] |
Zur
Parametrisierung von Substituenten : Der
Einfluss von Fluor und anderen
Heteroatomen auf OH-, NH- und
CH-Aciditäten.
M. Schlosser
Angew. Chem. 110 (1998), 1538 – 1556. |
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[27a] |
About the
Parametrization of Substituents :
Fluorine and Other Heteroatom Effects on
OH-, NH- and CH-Acidities.
M. Schlosser
Angew. Chem. Int. Ed. Engl. 37 (1998),
1496 – 1513. |
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1999 |
[28] |
The Chemical
and Physiological Size of Fluorine.
M. Schlosser
Enantiocontrolled Synthesis of
Fluoroorganic Compounds: Stereochemical
Challenges and Biomedicinal Targets (ed.
: V.A. Soloshonok), Wiley, Chichester,
1999, 613 – 659. |
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2001 |
[29] |
The
Organometallic Approach to Molecular
Diversity: Halogens as Helpers.
M. Schlosser
Eur.J. Org. Chem. 2001, 3975 – 3984. |
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2002 |
[30] |
Organoalkali
Chemistry.
M. Schlosser
Organometallics in Synthesis : A Manual
(ed. : M. Schlosser), completely revised
and extended second edition (1243 pp.),
Wiley, Chichester, 2002, 1 – 352. |
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2004 |
[31] |
The
Preparation of Organolithium Reagents
and Intermediates.
F. Leroux, M. Schlosser, I. Marek, E.
Zohar
Patai's Chemistry of Functional Groups (ed.:
Z. Rappoport), Wiley, Chichester, 2004,
pp. 435 – 493. |
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2005 |
[32] |
Der 2 × 3
Werkzeugkasten der metallorganischen
Methoden zur regiochemisch erschöpfenden
Funktionalisierung.
M. Schlosser
Angew. Chem. 116 (2005), 380 – 398. |
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[32a] |
The 3 × 2
Toolbox of Organometallic Methods for
Regiochemically Exhaustive
Functionalizations.
M. Schlosser
Angew. Chem. Int.Ed. Engl. 44 (2005),
376 - 393. |
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[33] |
Regioexhaustive Functionalizations: To
Miss an Isomer Means to Miss a Chance.
M. Schlosser
ACS Symposium Series (ed.: V.A.
Soloshonok), Am. Chem. Soc., Washington,
2005, pp. 218 - 231. |
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[34] |
a-Fluorinated
Ethers, Thioethers and Amines:
Anomerically Biased Species.
F. Leroux, P. Jeschke, M. Schlosser
Chem. Rev. 105 (2005), 827 - 856. |
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II. RESEARCH
ARTICLES ("FULL PAPERS") AND SHORT
COMMUNICATIONS |
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2003 |
[269] |
Sequestered
Alkyllithiums : Why Phenyllithium Alone
is Suitable for Betaine-Ylid Generation.
Q. Wang, D. Deredas, C. Huynh, M.
Schlosser
Chem. Eur. J. 9 (2003), 570 - 574. |
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[270] |
Organometallic Control over the
Regiospecificity of Functionalization
Reactions : 1,2,3-Trifluorobenzene and
Bromo Derivatives Thereof as Substrates
C. Heiss, M. Schlosser
Eur. J. Org. Chem. 2003, 447 - 451. |
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[271] |
A Homologous
Series of O- and N-Functionalized
2,2-Difluoro-1,3-benzodioxoles : An
Exercise in Organometallic Methodology
M. Schlosser, J. Gorecka, E. Castagnetti
Eur. J. Org. Chem. 2003, 452 - 462. |
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[272] |
Recommendable
Routes to Trifluoromethyl-Substituted
Pyridine- and Quinolinecarboxylic Acids
F. Cottet, M. Marull, O. Lefebvre, M.
Schlosser
Eur. J. Org. Chem. 2003, 1559 - 1568. |
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[273] |
The Direct
Metalation and Subsequent
Functionalization of Trifluoromethyl
Substituted Pyridines and Quinolines
M. Schlosser, M. Marull
Eur. J. Org. Chem. 2003, 1569 - 1575. |
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[274] |
Selective and
Efficient Elaboration of 2-(Trifluoromethyl)quinolinones
M. Marull, M. Schlosser
Eur. J. Org. Chem. 2003, 1576 - 1588. |
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[275] |
Trifluoromethoxy Substituted Anilines :
Metalation as the Key Step for
Structural Elaboration
F. Leroux, E. Castagnetti, M. Schlosser
J. Org. Chem. 68 (2003), 4693 – 4699. |
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[276] |
4-(Trifluoromethyl)quinoline
Derivatives
O. Lefebvre, M. Marull, M. Schlosser
Eur. J. Org. Chem. 2003, 2115 - 2121. |
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[277] |
Exploring
Structural Opportunities : The
Regioflexible Substitution of
1,3-Difluorobenzene
M. Schlosser, C. Heiss
Eur. J. Org. Chem. 2003, 4618 - 4624 |
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[278] |
Buttressing
Effects Rerouting the Deprotonation and
Functionalization of 1,3-Dichloro- and
1,3-Dibromobenzene
C. Heiss, E. Marzi, M. Schlosser
Eur. J. Org. Chem. 2003, 4625 - 4629. |
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2004 |
[279] |
An Improved
Access to 4-Trifluoromethyl-2(H)-quinolinones
: The "Watering" Protocol
M. Marull, O. Lefebvre, M. Schlosser
Eur. J. Org. Chem. 2004, 54 - 63. |
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[280] |
Deprotonation-Triggered Heavy Halogen
Migration As a Key to the Structural
Elaboration of
2,2-Difluoro-1,3-benzodioxole
J. Gorecka, F. Leroux, M. Schlosser
Eur. J. Org. Chem. 2004, 64 - 68. |
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[281] |
Atropisomeric
Biarylbisphosphines Derived from
2,2-Difluoro-1,3-benzodioxol
F. Leroux, J. Gorecka, M. Schlosser
Synthesis. 2004, 326 - 328. |
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[282] |
Regioflexibility in the
Functionalization of Multiply
Halogenated Quinolines
M. Marull, M. Schlosser
Eur. J. Org. Chem. 2004, 1008 - 1013. |
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[283] |
The
Superbase-Mediated Pairwise Substitution
of the 2,2'- and 6,6'-Positions in a
Biphenyl Derivative
M. Schlosser, G. Mangano, F. Leroux
Eur. J. Org. Chem. 2004, 1014 - 1017. |
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[284] |
The
Structural Proliferation of
2,6-Difluoropyridine Through
Organometallic Intermediates
M. Schlosser, T. Rausis
Eur. J. Org. Chem. 2004, 1018 - 1024. |
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[285] |
The
Regioexhaustive Functionalization of
Difluorophenols and Trifluorophenols
through Organometallic Intermediates
E. Marzi, J. Gorecka, M. Schlosser
Synthesis 2004, 1609 – 1618. |
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[286] |
Brominated
4-(Trifluoromethyl)pyrimidines: A
Convenient Access to Versatile
Intermediates
L. Ondi, O. Lefebvre, M. Schlosser
Eur. J. Org. Chem. 2004, 3714 – 3718. |
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[287] |
β,β-Difluoro
Analogs of α-Oxo-β-phenylpropionic Acid
and Phenylalanine
M. Schlosser, N. Brügger, W. Schmidt, N.
Amrhein
Tetrahedron 60 (2004), 7731 -7742. |
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[288] |
Three Chloro(trifluoromethyl)pyridines
as Model Substrates for Regioexhaustive
Functionalization
F. Cottet, M. Schlosser
Eur. J. Org. Chem. 2004, 3793 – 3798. |
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[289] |
Further Site
Selective Metalations and
Functionalizations of Chloro-, Bromo-and
Iodo(trifluoromethyl)pyridines
F. Cottet, M. Marull, F. Mongin, D.
Espinoza, M. Schlosser
Synthesis 2004, 1619 - 1624. |
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[290] |
Logistic
Flexibility in the Preparation of
Isomeric Halopyridine Carboxylic Acids
F. Cottet, M. Schlosser
Tetrahedron, 60 (2004), 11869 – 11874. |
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[291] |
Buttressing
Effects on Haloarene Deprotonation: A
Merely Kinetic or Also Thermodynamic
Phenomenon ?
J. Gorecka, C. Heiss, R. Scopelliti, M.
Schlosser
Org.Lett. 6 (2004), 4591 – 4593. |
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2005 |
[292] |
Rerouting
Nucleophilic Attack from the 4-Position
to the 2- or 6-Position of
2,4-Dihalopyridines and
2,4,6-Trihalopyridines: The Solution to
a Long-Standing Problem
M. Schlosser, T. Rausis, C. Bobbio
Org. Lett.7 (2005), 127 – 129. |
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[293] |
Metalation-Functionalization Sequences
Applied to 3-Fluoroquinolines
L. Ondi, J.-N. Volle, M. Schlosser
Tetrahedron 61 (2005), 717 – 725. |
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[294] |
The
Site-Selective Functionalization of
Halogen-Bearing Phenols: An Exercise in
Diversity-Oriented Organometallic
Synthesis
E. Marzi, M. Schlosser
Tetrahedron 61 (2005), 3393 – 3401. |
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[295] |
Removal of
Fluorine From and Introduction of
Fluorine- into Polyhalopyridines : -An
Exercise in Nucleophilic Hetarenic
Substitution
C. Bobbio, T. Rausis, M. Schlosser
Chem. Eur. J. 11 (2005) 1251 – 1256. |
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[296] |
Converting
Core Compounds into Building Blocks: The
Concept of Regiochemically Exhaustive
Functionalization
E. Marzi, C. Bobbio, F. Cottet, M.
Schlosser
Chem. Eur. J. 11 (2005), 1903 – 1910. |
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[297] |
The Gas Phase
Acidity of Oligofluorobenzenes and
Oligochlorobenzenes: About the
Additivity and Non-Additivity of
Substituent Effects
I. Hyla-Kryspin, S. Grimme, H.H. Büker,
N.M.M. Nibbering, F. Cottet, M.
Schlosser
Eur. J. Org. Chem. 2005, 2116 – 2123. |
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[298] |
Promoting or
Preventing Haloaryllithium
Isomerizations: Differential Basicities
and Solvent Effects as the Crucial
Variables
C. Heiss, T. Rausis, M. Schlosser
Synthesis 2005, 617 – 621. |
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[299] |
The "Aryne"
Route to (Trifluoromethyl)naphthalenes
and Congeners
F. Bailly, F. Cottet, M. Schlosser
Synthesis 2005, 791 – 797. |
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[300] |
The
Site-Selective Metalation of 1- and 2-(Trifluoromethyl)-naphthalenes
F. Cottet, E. Castagnetti, M. Schlosser
Synthesis 2005, 798 – 803. |
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[301] |
Regiochemically Flexible Substitutions
of Di-, Tri- and Tetra-Halopyridines:
The Trialkylsilyl Trick
C. Bobbio, M. Schlosser, T. Rausis
J. Org. Chem.70 (2005), 2494 - 2502. |
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[302] |
Introducing
Functional Groups Selectively into Each
Vacant Position of 2-Fluoropyridine,
2,3-Difluoropyridine and
2,5-Difluoropyridine
C. Bobbio, M. Schlosser
J. Org. Chem. 70 (2005), 3039 – 3046. |
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[303] |
A Large-Scale,
Low-Cost Access to the Lithium
2,2,6,6-Tetramethylpiperidide Precursor
D. Kampmann, G. Stuhlmüller, R. Simon,
F.Cottet, F. Leroux, M. Schlosser
Synthesis 2005, 1028 – 1029.. |
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[304] |
The Kinetic
Acidity of Oligofluorobenzenes
Correlated with their Gas Phase
Deprotonation Energies
E. Marzi, M. Schlosser
Chem. Eur. J. 11 (2005), 3449 – 3454. |
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[305] |
p-Arene/Metal
Binding: Not Merely a Structure, But
also a Reactivity Issue
E. Masson, M. Schlosser
Org. Lett. 7 (2005), 1923 – 1925. |
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[306] |
The
Reactivity of 2-Fluoro-and
2-Chloropyridines Toward Sodium Ethoxide:
Factors Governing the Rates of
Nucleophilic (Het)Aromatic Substitutions
M. Schlosser, T. Rausis
Helv. Chim. Acta 88 (2005), 1240 – 1249. |
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[307] |
The
Regioselective Metalation of All Six
Dichlorobenzotrifluorides
E. Masson, E. Marzi, C. Bobbio, F.
Cottet, M. Schlosser
Eur. J. Org. Chem. 2005, 4393 – 4400. |
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[308] |
Fluoronaphthalene Building Blocks via
Arynes : A Solution to the Problem of
Positional Selectivity
E. Masson, M. Schlosser
Eur. J. Org. Chem. 2005, 4401 – 4405. |
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[309] |
The Abnormal
Behavior of an Atropisomer : 3,3'-Dibromo-1,1'-difluoro-2,2'-binaphthyl
Reacting with Alkyllithium Compounds
F. Leroux, G. Mangano, M. Schlosser
Eur. J. Org. Chem. 2005, 5049 – 5054. |
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[310] |
meta- Rather
than ortho-Directed Metalations :
Buttressing Effects Prejudicing the
Reactivity of (2,6-Dihalophenyl)silanes
C. HeissF. Cottet, M. Schlosser
Eur. J. Org. Chem. 2005, 5236 – 5241. |
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[311] |
Fluorine-Flanked
Congested Sites: Minimal, Though
Perceptible Buttressing Effects on the
Proton Mobility of Arenes
C. Heiss, F. Leroux, M. Schlosser
Eur. J. Org. Chem. 2005, 5242 – 5247. |
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III. PUBLISHED
LECTURE SUMMARIES |
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2001 |
[57] |
The
Functionalization of (Trifluoromethyl)pyridines
and -quinolines : their Site Selective
Deprotonation as the Key Step
M. Marull, R. Bregonzi, M. Schlosser
13th European Symposium on Fluorine
Chemistry, Bordeaux, 15 – 20 July 2001,
Congress Proceedings, p. 2P15 |
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[58] |
Various Ways
to Functionalize Quinolines Carrying
Both Bromo and Trifluoromethyl
Substituents
M. Marull, O. Lefebvre
13th European Symposium on Fluorine
Chemistry, Bordeaux, 15 – 20 July 2001,
Congress Proceedings, p. 2P16 |
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[59] |
N-(4-Biphenylmethyl)imidazoles as
Potential Receptor Ligands : Metabolic
Robustness Due to Fluorine Substitution
F. Leroux , N. Nicod
Perugia Fluorine Days, Perugia, 14 – 16
October 2001, Congress Proceedings |
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[60] |
Fluoro-Substituted Acrylates as
Precursors to Functionalized
5-Fluoropyrazoles and 5-(Trifluoromethyl)pyrazoles
J.-N. Volle, M. Schlosser
Perugia Fluorine Days, Perugia, 14 – 16
October 2001, Congress Proceedings |
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2002 |
[61] |
Préparation
d'hétérocycles azotés à partir du
4,4,4-trifluoroacétoacétate de méthyle
O. Lefebvre, M. Schlosser
GECO XLIII (Groupe d'Etude en Chimie
Organique, Sevrier (Lac d'Annecy), 1 – 6
September 2002) |
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[62] |
Métallation
régiosélective des phénols, alcools
benzyliques et 2-phényléthanols fluorés
ou trifluorométhylés
E. Marzi, M. Schlosser
GECO XLIII (Groupe d'Etude en Chimie
Organique, Sevrier (Lac d'Annecy), 1 – 6
September 2002) |
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[63] |
Métallation
régiosélective de pyridines et
quinoléines trifluoromethylés
M. Marull, M. Schlosser
GECO XLIII (Groupe d'Etude en Chimie
Organique, Sevrier (Lac d'Annecy), 1 – 6
September 2002) |
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2003 |
[64] |
Fluorine and
Other Heteroelement Effects on Aromatic
CH-Acidities
J. Gorecka, E. Marzi, E. Masson, S.
Javor, F. Leroux, M. Schlosser
International Symposium "Fluorine in the
Life Sciences", Bürgenstock (Lucerne), 6
– 9 July 2003, Congress Proceedings, p.
62 |
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[65] |
Relative
Kinetic and Thermodynamic Acidities of
Trialkyl(halophenyl)silanes : Unmasking
a Mysterious Buttressing Effect
C. Heiss, E. Marzi, F. Mongin, M.
Schlosser
International Symposium "Fluorine in the
Life Sciences", Bürgenstock (Lucerne), 6
– 9 July 2003, Congress Proceedings, p.
66 |
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[66] |
Optional Site
Selectivity Implemented in Nucleophilic
Substitutions of 2,4- and
2,6-Dihalopyridines : A Solution to a
Long-Standing Problem
C. Bobbio, T. Rausis, M. Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 75 |
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[67] |
(Trifluoromethyl)pyridinecarboxylic
Acids and Chloro or Bromo Substituted
Congeners
F. Cottet, M. Marull, M. Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 77 |
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[68] |
The
Regiochemically Exhaustive
Functionalization of Fluoro Substituted
Indoles
A. Ginanneschi, E. Castagnetti, M.
Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 79 |
|
|
[69] |
How to Kill
Two Birds With One Stone : An Optional
Entry to the 4-Bromo-2- and 2-Bromo-4-(trifluoromethyl)quinoline
Families
O. Lefebvre, M. Marull, M. Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 81 |
|
|
[70] |
The
Regiochemically Exhaustive
Functionalization of 4-Bromo-2-(trifluoromethyl)quinolines
: A Case Study
M. Marull, M. Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 82 |
|
|
[71] |
The Concept
of the Regiochemically Exhaustive
Functionalization of Arenes and
Hetarenes
E. Marzi, M. Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 83 |
|
|
[72] |
The Aryne
Route to Fluoro, Trifluoromethoxy and
Trifluoromethyl Substituted Naphthalene
Derivatives
E. Masson, F. Bailly, F. Cottet, E.
Castagnetti, M. Schlosser
International Symposium, "Fluorine in
the Life Sciences", Bürgenstock
(Lucerne), 6 – 9 July 2003, Congress
Proceedings, p. 85 |
|
|
|
|
|
2004 |
[73] |
The 2 x 3
Toolbox of Organometallic Mutant Methods
Enabling Regiochemically Exhaustive
Functionalizations
E. Masson, M. Schlosser
International Symposium on Fine
Chemistry and Functional Polymers.
Hohhot, Inner Mongolia, 16 – 19 August
2004, Congress Proceedings, pp. 20 - 21 |
|
2005 |
[74] |
The
Structural Proliferation of Fluorinated
Building Blocks by Regiochemically
Exhaustive Functionalization
M. Schlosser
American Chemical Society, Annual
Meeting, Washington, 28 Aug. – 1 Sept.
2005, Congress, booklet, PL-7 |
|
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